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\label{sec:cuprates2}  With the hindsight of the experience of our first attempt in designing new  cuprates, we revisited the question of designing novel cuprates from a broader viewpoint. As shown in Fig.~\ref{fig:stack}, we view the cuprates as a stack of functional layers, with the composition of each layer chosen to play a specific role. The Historically, most theoretical effort has been focused on the  central copper oxide (CuO$_2$) plane supports  superconductivity and roughly constrains layer, as the superconducting cooper pairs reside in this plane. However,  thein-plane lattice constant. The  remaining layers must tune the chemical potential of the are equally important: they are responsible for isolating each  CuO$_2$ layer plane to produce a 2D system  without introducing  rumplingthe plane  or introducing disorder, other structural distortions,  and isolate each for tuning the chemical potential while ideally protecting the  CuO$_2$ plane to  create a 2D system. from the chemical disorder of the dopants.