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\label{sec:cuprates2}  With the hindsight of the experience of our first attempt in designing new cuprates, we revisited the question of designing novel cuprates from a broader viewpoint. Taking the Hg-based cuprates as an example (Fig.~\ref{fig:stack}), we view viewed  the cuprates as a stack of functional layers, with the composition of each layer chosen to play a specific role. The central copper oxide (CuO$_2$) plane supports superconductivity and roughly constrains the in-plane lattice constant. The remaining layers must tune the chemical potential of the CuO$_2$ layer without rumpling the plane or introducing disorder, and isolate each CuO$_2$ plane to create a 2D system.