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\subsection{\textbf{Keywords:}}  bias;meta-analysis;oncology;quality;systematic review  \section{Introduction}  The use of systematic reviews and meta-analyses has become of increasing importance in evidence based medicine for clinicians to seek out consistent and reliable information on treatments and care guidelines in medicine \cite{14764293}. In part, the reasoning for reliance on systematic reviews and meta-analyses is that both are considered to be helpful due to pooling of results of multiple studies to provide a broader view of information of interest, and by broadening the pool of data, the idea is that bias would become less of an issue in studies \cite{7500513}. Quality assessment is a crucial component of any study and consequences of inadequate quality reporting or evaluation within research studies, can lead to exaggerated treatment effects when bias of participants is not taken into account in study design  \section{Methods}  \subsection{Search Criteria and Eligibility}  
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