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Caitlin Yeaton Rivers edited Case tree plots.tex
over 10 years ago
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\subsection*{Case tree plots}
The Case tree plots depict clusters of disease over time. Placement along the x-axis
represents time, and corresponds with the date of illness onset for the
y axis case. When the onset date is not known, diagnosis date may be used instead. The y-axis value represents
the case generation. Nodes at generation 1 are human cases acquired from an animal source. If that infected human passes the disease to two other humans, those two subsequent cases are plotted at generation 2, and connected to the node of origin by edges. Cases that do not belong to a cluster are represented as independent nodes on the plot.
The meaning of the color of the node varies based on the node attribute. In many cases, color simply signifies membership to a human to human cluster. However, it could also represent health status (e.g. alive, dead), the sex of the patient, or any other categorical attribute.
The meaning of the color of the node varies based on the node attribute. In many cases, color simply signifies membership to a human to human cluster. However, it could also represent health status (e.g. alive, dead), the sex of the patient, or any other categorical attribute.
To generate a case tree plot, users provide a line listing with, at minimum:
unique case
ids, identifiers, the date of illness
onset, onset (or the date the illness was reported, if onset date is not available), and cluster membership, as seen in table~\ref{tab:linelist}. Any additional
relevant variables like patient age and sex may also be included.
\begin{table}
\centering
...
\label{tab:linelist}
\end{table}
Users must also provide the mean and standard deviation of the generation time between cases.
Because generation time is not always known in the early days of the outbreak, the incubation period may be a reasonable proxy. The line listing need not specify the chain of transmission; the case tree plot generator will estimate the chain of transmission based on the onset dates based generation time values. Cases belonging to the same cluster that have an onset date within one standard deviation of the mean generation time are assumed to be linked.