Kim H. Parker edited NOTES_1_The_method_needs__.tex  over 8 years ago

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A fundamental problem in exploring this method is the absence of any direct measurements of the wave speed in coronary arteries. Until a method for direct measurement is discovered, the validity of any estimation of coronary artery wave speed can only be inferred, not demonstrated. The values given above are somewhat higher than most estimates of coronary wave speeds, but not outside of the realms of possibility. The large coronary arteries run in grooves in the surface of the myocardium and are covered by the pericardial membrane. It is therefore unlikely that their distensibility is only a function of the distensibility of their walls. Values of the wave speed in other muscular systemic arteries of similar diameter to the coronary arteries frequently are generally well in excess of 10 m/s. and the value increases as the distensibility of the artery decreases. The preliminary results given above seem promising and warrant further investigation.  NOTES:  1. The method needs to be applied to a number of measurements in different coronary arteries in different patients. This is under way.