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Kim H. Parker edited textbf_The_fundamental_errors_The__.tex
almost 9 years ago
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\textbf{The fundamental errors}
The first major error is the assumption that RWC and iFR are directly related and that conclusions drawn from
either of the two ideas can be
treated as one. directly applied to the other. This assumption is not stated overtly but it permeates almost all of their discussion.
In fact, iFR makes no use of the reservoir-wave concept and we are unaware of any publications before WSW that imply that it does. We did look into the idea of applying the reservoir pressure
using measured pressure and flow velocity to our coronary measurements and very quickly decided that it added nothing to the wave intensity
analysis. analysis based on the measured pressure and flow. It is our belief that the reservoir pressure hypothesis is very likely to be inappropriate in the coronary arteries because of their limited compliance and their proximity to terminal reflection sites and other sources of backward travelling waves. We have used reservoir pressure analysis of pressure measured in various distal locations, e.g. the radial artery in the analysis of the CAFE study and while we have some reservations about their interpretation in relation to current theories about the
reservoir, reservoir pressure, one cannot contest their
epidemiological predictive power.
Conversely, iFR played no role in the development of the reservoir-wave hypothesis which antedated iFR by more than a decade. After the development of iFR there has never been any attempt to apply that principle to Pr.
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