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\documentclass[12pt]{article}  \usepackage[utf8]{inputenc}  \usepackage{amsmath}  \title{Rate Constants}  \date{}  \begin{document}  \maketitle  The consecutive two-step reversible reaction of the form   \begin{equation}  A \mathrel{\mathop{\longleftrightarrow}^{\mathrm{\textit{ k }_1}}_{\mathrm{\textit{ k }_{-1}}}} B \mathrel{\mathop{\longleftrightarrow}^{\mathrm{\textit{ k }_2}}_{\mathrm{\textit{ k }_{-2}}}} C