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### Signal fitting  #### Fitting function for transients  The function used for fitting Ca2+ release events is shown on Figure \ref{fig:fit}. The shape of the function is described by 4 parameters: amplitude (\(A\)), rise and decay time constants (\(\tau_{r},\tau_{d}\)) and plateau duration (\(d\)). An additional parameter (\(\mu\)) determines the time when the maximum is reached. The function describing a transient is:   \[ g(A, d, \tau_{d}, \tau_{r}, \mu, t) = \] The transient consists of four phases: zero level before the onset of the transient, an exponential increase with time constant \(\tau_r\) starging when \(t=\mu-2\tau_r\), a plateau phase of duration \(d\) starting at \(t=\mu\) and an exponential decay with time constant \(\tau_d\) starting at \(t=\mu+d\)