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Ardo Illaste Merged master into authorea
almost 10 years ago
Commit id: 7fb38221096cae5cd7008b6a264610a7b839f914
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First, the highest ranked regions are fitted with the extended fit function. After parameter optimization with the signal in the region is fitted with a linear model. For both models the corrected Akaike Information Criterion (AICc \cite{Burnham_2004}) is calculated and the region is taken to contain an event only if the AICc for the fit function is less than the AICc for the line. This ensures that the fit obtained with the fit function is good enough to justify the use of a more complicated model. After this each the fits are subtracted from the original signal. This allows the lower ranked regions to be fitted with reduced interference from higher ranking regions (see supporting info figures). When all regions have been fitted and their fits subtracted from the signal, the remaining signal is fitted with a polynomial function to approximate the baseline fluorescence.
At each pass regions which have no overlaps and regions which only overlap with In the second stage signals from regions
having a lower peak SNR are fitted
(Figure \ref{fig:regs}D). After a successful again. Before performing the fit, the
result baseline and previously obtained fits for other regions are subtracted from the raw signal. This allows the simpler fit function to be used as subtraction eliminates the need for
the extra baseline parameters (B and C). Once region is
fitted in this manner the results are subtracted from the
original raw signal
to estimate the baseline again. If the relative change between the first and
region detection second fit stage is
performed again, followed by fitting. This process large then stage 2 is
continued until no more regions are detected or successfully fitted. repeated.