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Ernst Niggli edited Introduction.md
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# Introduction
Elementary Ca2+ signaling events occur in many different cell types and exhibit a variety of spatiotemporal features, according to which they were
classified and classified. For such events an ever growing nomenclature has been developed (e.g. Ca2+ sparks, puffs, blinks, quarks, etc., for review see Niggli, E., and N. Shirokova. 2007. A guide to sparkology: The taxonomy of elementary cellular Ca2+ signaling events. Cell Calcium. 42:379–387.). More complex Ca2+ signals, such as Ca2+ waves and whole-cell Ca2+ transients are often composed of a variable number of such elementary events.
Numerous methods exist for analysing Ca2+ sparks and other types of elementary and global Ca2+ signals in confocal linescan images. These employ various different approaches: noise tresholding \cite{R_os_2001,Picht_2007}, wavelet transform \cite{Szab__2010}, etc.