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# Introduction  Numerous methods exist for analysing Ca2+  sparks and other types of elementary and global Ca2+ signals  in confocal linescans. linescan images.  These employ various different approaches: noise tresholding \cite{R_os_2001,Picht_2007}, wavelet transform \cite{Szab__2010}, etc. Recently, a method was developed by Tian et al., \cite{Tian_2012}, where the fluorescence time trace in each pixel is fitted and provides a practically noise free approximation of the original fluorescence data. This pixel-by-pixel method had, however, several limitations which made it impractical to be used for Ca2+ release event detection.