Ardo Illaste edited Introduction.md  about 10 years ago

Commit id: 1a740832a2c8b18c2f8d7d7ac8f24b9415c5da07

deletions | additions      

       

#Introduction  Numerous methods exist for analysing sparks in confocal linescans. These employ various different approaches: noise tresholding \cite{R_os_2001,Picht_2007} \cite{R_os_2001,Picht_2007}, wavelet transform \cite{Szab__2010}, etc.  Recently, a method was developed by Tian et al., \cite{Tian_2012}, where fluorescence time trace in each pixel is fitted and provides a practically noise free approximation of the original fluorescence data. This pixel-by-pixel method had, however, several limitations which made it impractical for use with Ca2+ release event detection.   Here we extend the method by Tian et al., in several ways.