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Klaus edited Introduction.tex
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R_{min} \text{(nm)} = 0.066 \cdot \text{MW}^{1/3} \label{eq:Erickson}
\end{equation}
However, proteins have a rough surface, are often not perfectly spherical, and their charge affects
the their diffusion
of a molecule in solution. The hydrodynamic radius $R_h$, defined as the radius of a hard sphere that diffuses at the same rate as the solute, takes these effects into account. The hydrodynamic radius is important in predicting transretinal penetration.\cite{Jackson2003,Ambati2000a}
Small-angle scattering studies using X-rays (SAXS) or neutrons (SANS) \cite{Svergun_2013} as well as dynamic light scattering (DLS) \cite{Pecora_1985,Hong_2009} and nuclear magnetic resonance (NMR) techniques \cite{Wilkins1999} have been used for measuring $R_h$. Empirical relationships have been defined between $R_h$ and the number of amino acids $N$ (related to the MW by \(N = \frac{\text{MW}}{110 \text{ Da}}\)), for example, by Wilkins \textit{et al.}\ \cite{Wilkins1999}
\begin{equation}