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%\subsection{Radius calculation from MW}  Many factors, such as the molecular size and shape, will influence how intravitreal drugs cross the vitreous, and retina, to reach diseased macular and choroidal tissue.\cite{Foulds1985, Gisladottir2009, Srikantha2012} It is well known that increasing MW reducesthe speed of  diffusion across biological tissue,\cite{Maurice1977, Pitkanen2005, Geroski2001} and other studies have shown that the molecular radius is a better predictor of tissue penetration than MW.\cite{Ambati2002, Ambati2000a, Geroski2001, Bohrer1984, Ohlson2001, Venturoli2005} It is possible to estimate the radius of a protein from the MW. Erickson uses the fact that all proteins have approximately the same density, 1.37 g/cm$^3$, to calculate the protein volume from the MW.\cite{Erickson2009} Assuming a smooth spherical shape, this yields a minimum possible radius  \begin{equation}