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@Article{Ambati2002,
Title title =
{Transscleral {{Transscleral drug delivery to the retina and
choroid},
Author choroid}},
author = {Ambati, J. and Adamis, A. P.},
Journal journal = {Prog. Retin. Eye Res.},
Year year = {2002},
Number number = {2},
Pages pages = {145-151},
Volume volume =
{21} {21},
}
@Article{Ambati2000a,
Title title =
{Diffusion {{Diffusion of high molecular weight compounds through
sclera},
Author sclera}},
author = {Ambati, J. and Canakis, C. S. and Miller, J. W. and Gragoudas, E. S. and Edwards, A. and Weissgold, D. J. and Kim, I. and Delori, F. C. and Adamis, A. P.},
Journal journal = {Invest. Ophthalmol. Vis. Sci.},
Year year = {2000},
Number number = {5},
Pages pages = {1181-1185},
Volume volume =
{41} {41},
}
@Article{Ambati2000b,
Title title =
{Transscleral {{Transscleral delivery of bioactive protein to the choroid and
retina},
Author retina}},
author = {Ambati, J. and Gragoudas, E. S. and Miller, J. W. and You, T. T. and Miyamoto, K. and Delori, F. C. and Adamis, A.
P. },
Journal P.},
journal = {Invest. Ophthalmol. Vis. Sci.},
Year year = {2000},
Number number = {5},
Pages pages = {1186-1191},
Volume volume =
{41} {41},
}
@Article{Axelrod1976,
Title title =
{Mobility {{Mobility measurement by analysis of fluorescence photobleaching recovery
kinetics},
Author kinetics}},
author = {Axelrod, D. and Koppel, D.E. and Schlessinger, J. and Elson, E. and Webb, W.W.},
Journal journal = {Biophys. J.},
Year year = {1976},
Number number = {9},
Pages pages = {1055-1069},
Volume volume =
{16} {16},
}
@Article{Axelsson1978,
Title = {Characterization of proteins and other macromolecules by agarose gel chromatography},
Author = {Inge Axelsson},
Journal = {J. Chromatogr.},
Year = {1978},
Number = {1},
Pages = {21 - 32},
Volume = {152},
Doi @Article{Axelsson1978,
title = {{Characterization of proteins and other macromolecules by agarose gel chromatography}},
author = {Inge Axelsson},
journal = {J. Chromatogr.},
year = {1978},
number = {1},
pages = {21 - 32},
volume = {152},
doi = {http://dx.doi.org/10.1016/S0021-9673(00)85330-3},
ISSN issn = {0021-9673},
Review review = {Ref for BSA radius 3.48 nm quoted in Wikipedia.},
Url url =
{http://www.sciencedirect.com/science/article/pii/S0021967300853303} {http://www.sciencedirect.com/science/article/pii/S0021967300853303},
}
@Article{Bohrer1984,
Title title =
{Hindered {{Hindered diffusion of dextran and ficoll in microporous
membranes},
Author membranes}},
author = {Bohrer, M. P. and Patterson, Gary D. and Carroll, P. J.},
Journal journal = {Macromolecules},
Year year = {1984},
Number number = {6},
Pages pages = {1170-1173},
Volume volume =
{17} {17},
}
@Article{Bunce2010,
Title title =
{Causes {{Causes of blind and partial sight certifications in {E}ngland and {W}ales: {A}pril 2007-{M}arch
2008},
Author 2008}},
author = {Bunce, C. and Xing, W. and Wormald, R.},
Journal journal = {Eye (Lond)},
Year year = {2010},
Number number = {11},
Pages pages = {1692-1699},
Volume volume =
{24} {24},
}
@Article{Callanan2008,
Title title =
{Treatment {{Treatment of posterior uveitis with a fluocinolone acetonide implant: three-year clinical trial
results},
Author results}},
author = {Callanan, D. G. and Jaffe, G. J. and Martin, D. F. and Pearson, P. A. and Comstock, T. L.},
Journal journal = {Arch. Ophthalmol.},
Year year = {2008},
Number number = {9},
Pages pages = {1191-1201},
Volume volume =
{126} {126},
}
@Article{Danysh2010,
Title title =
{Characterizing {{Characterizing molecular diffusion in the lens
capsule},
Author capsule}},
author = {Danysh, B. P. and Patel, T. P. and Czymmek, K. J. and Edwards, D. A. and Wang, L. and Pande, J. and Duncan, M.
K. },
Journal K.},
journal = {Matrix Biol.},
Year year = {2010},
Number number = {3},
Pages pages = {228-236},
Volume volume =
{29} {29},
}
@Article{Dill2011,
Title = {Physical limits of cells and proteomes},
Author = {Dill, K. A. and Ghosh, K. and Schmit, J. D.},
Journal = {P. Natl. Acad. Sci. USA},
Year = {2011},
Number = {44},
Pages = {17876-17882},
Volume = {108},
Doi @Article{Dill2011,
title = {{Physical limits of cells and proteomes}},
author = {Dill, K. A. and Ghosh, K. and Schmit, J. D.},
journal = {P. Natl. Acad. Sci. USA},
year = {2011},
number = {44},
pages = {17876-17882},
volume = {108},
doi = {10.1073/pnas.1114477108},
Eprint eprint = {http://www.pnas.org/content/108/44/17876.full.pdf},
Url url =
{http://www.pnas.org/content/108/44/17876.abstract} {http://www.pnas.org/content/108/44/17876.abstract},
}
@Article{Edelhauser2010,
Title title =
{Ophthalmic {{Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical
applications},
Author applications}},
author = {Edelhauser, H. F. and Rowe-Rendleman, C. L. and Robinson, M. R. and Dawson, D. G. and Chader, G. J. and Grossniklaus, H. E. and Rittenhouse, K. D. and Wilson, C. G. and Weber, D. A. and Kuppermann, B. D. and Csaky, K. G. and Olsen, T. W. and Kompella, U. B. and Holers, V. M. and Hageman, G. S. and Gilger, B. C. and Campochiaro, P. A. and Whitcup, S. M. and Wong, W. T.},
Journal journal = {Invest. Ophthalmol. Vis. Sci.},
Year year = {2010},
Number number = {11},
Pages pages = {5403-5420},
Volume volume =
{51} {51},
}
@Article{Epstein1978,
Title title =
{Obstruction {{Obstruction of aqueous outflow by lens particles and by heavy-molecular-weight soluble lens
proteins},
Author proteins}},
author = {Epstein, D. L. and Jedziniak, J. A. and Grant, W.
M. },
Journal M.},
journal = {Invest. Ophthalmol. Vis. Sci.},
Year year = {1978},
Number number = {3},
Pages pages = {272-277},
Volume volume =
{17} {17},
}
@Article{Erickson2009,
Title title =
{Size {{Size and shape of protein molecules at the nanometer level determined by sedimentation, gel filtration, and electron
microscopy},
Author microscopy}},
author = {Erickson, H.
P. },
Journal P.},
journal = {Biol. Proced. Online},
Year year = {2009},
Pages pages = {32-51},
Volume volume =
{11} {11},
}
@Article{Ferrer2001,
Title title =
{The {{The conformation of serum albumin in solution: a combined phosphorescence depolarization-hydrodynamic modeling
study},
Author study}},
author = {Ferrer, M. L. and Duchowicz, R. and Carrasco, B. and de la Torre, J. G. and Acu\~na, A.
U. },
Journal U.},
journal = {Biophys. J.},
Year year = {2001},
Number number = {5},
Pages pages = {2422--2430},
Volume volume =
{80} {80},
}
@Article{Foulds1985,
Title title =
{Effect {{Effect of intravitreal hyaluronidase on the clearance of tritiated water from the vitreous to the
choroid},
Author choroid}},
author = {Foulds, W. S. and Allan, D. and Moseley, H. and Kyle, P.
M. },
Journal M.},
journal = {Br. J. Ophthalmol.},
Year year = {1985},
Number number = {7},
Pages pages = {529-532},
Volume volume =
{69} {69},
}
@Article{Gekko1981,
Title title =
{Mechanism {{Mechanism of protein stabilization by glycerol: preferential hydration in glycerol-water
mixtures},
Author mixtures}},
author = {Gekko, K. and Timasheff, S.
N. },
Journal N.},
journal = {Biochemistry},
Year year = {1981},
Number number = {16},
Pages pages = {4667-4676},
Volume volume =
{20} {20},
}
@Article{Geroski2001,
Title title =
{Transscleral {{Transscleral drug delivery for posterior segment
disease},
Author disease}},
author = {Geroski, D. H. and Edelhauser, H.
F. },
Journal F.},
journal = {Adv. Drug Deliv. Rev.},
Year year = {2001},
Number number = {1},
Pages pages = {37-48},
Volume volume =
{52} {52},
}
@Article{Gisladottir2009,
Title title =
{Diffusion {{Diffusion characteristics of vitreous humour and saline solution follow the {S}tokes {E}instein
equation},
Author equation}},
author = {Gisladottir, S. and Loftsson, T. and Stefansson,
E. },
Journal E.},
journal = {Graefes Arch. Clin. Exp. Ophthalmol.},
Year year = {2009},
Number number = {12},
Pages pages = {1677-1684},
Volume volume =
{247} {247},
}
@Article{Hirvonen2014_ol,
Title title =
{Wide-field {{Wide-field time-correlated single-photon counting (\textsc{TCSPC}) lifetime microscopy with microsecond time
resolution},
Author resolution}},
author = {L. M. Hirvonen and F. Festy and K. Suhling},
Journal journal = {Opt. Lett.},
Year year = {2014},
Number number = {19},
Pages pages = {5602--5605},
Volume volume = {39},
Abstract abstract = {A 1\&\#xA0;MHz frame rate complementary metal-oxide semiconductor (CMOS) camera was used in combination with an image intensifier for wide-field time-correlated single-photon counting (TCSPC) imaging. The system combines an ultrafast frame rate with single-photon sensitivity and was employed on a fluorescence microscope to image decays of ruthenium compound Ru(dpp) with lifetimes from around 1 to 5\&\#xA0;\&\#x3BC;s. A submicrowatt excitation power over the whole field of view is sufficient for this approach, and compatibility with live-cell imaging was demonstrated by imaging europium-containing beads with a lifetime of 570\&\#xA0;\&\#x3BC;s in living HeLa cells. A standard two-photon excitation scanning fluorescence lifetime imaging (FLIM) system was used to independently verify the lifetime for the europium beads. This approach brings together advantageous features for time-resolved live-cell imaging such as low excitation intensity, single-photon sensitivity, ultrafast camera frame rates, and short acquisition times.},
Doi doi = {10.1364/OL.39.005602},
Keywords keywords = {Photon counting; Low light level; Microscopy; Fluorescence microscopy; Lifetime-based sensing; Time-resolved imaging},
Owner owner = {liisa},
Publisher publisher = {OSA},
Timestamp timestamp =
{2015.05.13} {2015.05.13},
}
@Article{Hirvonen2015_njp,
Title = {Sub-$\mu$s time resolution in wide-field time-correlated single photon counting microscopy obtained from the photon event phosphor decay},
Author = {L. M. Hirvonen and Z. Petr\'{a}\v{s}ek and A. Beeby and K. Suhling},
Journal = {New J. Phys.},
Year = {2015},
Pages = {023032},
Volume = {17},
Doi @Article{Hirvonen2015_njp,
title = {{Sub-$\mu$s time resolution in wide-field time-correlated single photon counting microscopy obtained from the photon event phosphor decay}},
author = {L. M. Hirvonen and Z. Petr\'{a}\v{s}ek and A. Beeby and K. Suhling},
journal = {New J. Phys.},
year = {2015},
pages = {023032},
volume = {17},
doi = {10.1088/1367-2630/17/2/023032},
Owner owner = {liisa},
Timestamp timestamp =
{2015.05.13} {2015.05.13},
}
@Article{Imhof1994,
Title title =
{A {{A comparison between the long-time self-diffusion and low shear viscosity of concentrated dispersions of charged colloidal silica
spheres},
Author spheres}},
author = {Imhof, A and Van Blaaderen, A and Maret, G and Mellema, J and Dhont, JKG},
Journal journal = {The Journal of chemical physics},
Year year = {1994},
Number number = {3},
Pages pages = {2170-2181},
Volume volume =
{100} {100},
}
@Article{Inomata1977,
Title title =
{Exit {{Exit sites of uveoscleral flow of aqueous humor in cynomolgus monkey
eyes},
Author eyes}},
author = {Inomata, H. and Bill,
A. },
Journal A.},
journal = {Exp. Eye Res.},
Year year = {1977},
Number number = {2},
Pages pages = {113--118},
Volume volume =
{25} {25},
}
@Article{Jackson2003,
Title title =
{Human {{Human retinal molecular weight exclusion limit and estimate of species
variation},
Author variation}},
author = {Jackson, T. L. and Antcliff, R. J. and Hillenkamp, J. and Marshall,
J. },
Journal J.},
journal = {Invest. Ophthalmol. Vis. Sci.},
Year year = {2003},
Number number = {5},
Pages pages = {2141--2146},
Volume volume =
{44} {44},
}
@Article{Kang2009,
Title title =
{A {{A generalization of theory for two-dimensional fluorescence recovery after photobleaching applicable to confocal laser scanning
microscopes},
Author microscopes}},
author = {Kang, M. and Day, C. A. and Drake, K. and Kenworthy, A. K. and DiBenedetto,
E. },
Journal E.},
journal = {Biophys. J.},
Year year = {2009},
Number number = {5},
Pages pages = {1501--1511},
Volume volume =
{97} {97},
}
@Article{Kops‐Werkhoven1982,
Title = {Dynamic behavior of silica dispersions studied near the optical matching point},
Author = {Kops‐Werkhoven, M. M. and Fijnaut, H. M.},
Journal = {J. Chem. Phys.},
Year = {1982},
Number = {5},
Pages = {2242-2253},
Volume = {77},
Doi = {http://dx.doi.org/10.1063/1.444146},
Url = {http://scitation.aip.org/content/aip/journal/jcp/77/5/10.1063/1.444146}
}
@Book{Lakowicz2006,
Title title =
{Principles {{Principles of Fluorescence
Spectroscopy},
Author Spectroscopy}},
author = {Lakowicz, J. R.},
Publisher publisher = {Springer},
Year year = {2006},
Address address = {New York},
Edition edition =
{3rd} {3rd},
}
@Article{Li2011,
Title title =
{Effective {{Effective electrophoretic mobilities and charges of anti-{V}{E}{G}{F} proteins determined by capillary zone
electrophoresis},
Author electrophoresis}},
author = {Li, S. K. and Liddell, M. R. and Wen,
H. },
Journal H.},
journal = {J. Pharm. Biomed. Anal.},
Year year = {2011},
Number number = {3},
Pages pages = {603--607},
Volume volume =
{55} {55},
}
@Article{Wen2013,
Author={Wen, author = {Wen, H. and Hao, J. and Li, S. K.},
Title={{C}haracterization title = {{{C}haracterization of human sclera barrier properties for transscleral delivery of bevacizumab and
ranibizumab},
Journal={J. ranibizumab}},
journal = {J. Pharm. Sci.},
Year={2013},
Volume={102},
Number={3},
Pages={892--903}, year = {2013},
volume = {102},
number = {3},
pages = {892--903},
}
@Article{Maurice1977,
Title title =
{Diffusion {{Diffusion across the
sclera},
Author sclera}},
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J. },
Journal J.},
journal = {Exp. Eye Res.},
Year year = {1977},
Number number = {6},
Pages pages = {577--582},
Volume volume =
{25} {25},
}
@Article{McLaughlin2013,
Title title =
{Initial {{Initial exploration of oral pazopanib in healthy participants and patients with age-related macular
degeneration},
Author degeneration}},
author = {McLaughlin, M. M. and Paglione, M. G. and Slakter, J. and Tolentino, M. and Ye, L. and Xu, C. F. and Suttle, A. B. and Kim, R.
Y. },
Journal Y.},
journal = {JAMA Ophthalmol.},
Year year = {2013},
Number number = {12},
Pages pages = {1595--1601},
Volume volume =
{131} {131},
}
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Title = {Tracer diffusion in concentrated colloidal dispersions. III. Mean squared displacements and self‐diffusion coefficients},
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Journal = {J. Chem. Phys.},
Year = {1989},
Number = {1},
Pages = {552-559},
Volume = {91},
Doi @Article{vanMegen1989,
title = {{Tracer diffusion in concentrated colloidal dispersions. III. Mean squared displacements and self‐diffusion coefficients}},
author = {van Megen, W. and Underwood, S. M.},
journal = {J. Chem. Phys.},
year = {1989},
number = {1},
pages = {552-559},
volume = {91},
doi = {http://dx.doi.org/10.1063/1.457492},
Url url =
{http://scitation.aip.org/content/aip/journal/jcp/91/1/10.1063/1.457492} {http://scitation.aip.org/content/aip/journal/jcp/91/1/10.1063/1.457492},
}
@Article{Meyvis1999,
Title title =
{Fluorescence {{Fluorescence recovery after photobleaching: a versatile tool for mobility and interaction measurements in pharmaceutical
research},
Author research}},
author = {Meyvis, T. K. and De Smedt, S. C. and Van Oostveldt, P. and Demeester,
J. },
Journal J.},
journal = {Pharm. Res.},
Year year = {1999},
Number number = {8},
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Volume volume =
{16} {16},
}
@Article{Molokhia2009,
Title title =
{Transscleral {{Transscleral iontophoretic and intravitreal delivery of a macromolecule: study of ocular distribution in vivo and postmortem with
{M}{R}{I}},
Author {M}{R}{I}}},
author = {Molokhia, S. A. and Jeong, E. K. and Higuchi, W. I. and Li, S.
K. },
Journal K.},
journal = {Exp. Eye Res.},
Year year = {2009},
Number number = {3},
Pages pages = {418--425},
Volume volume =
{88} {88},
}
@Article{Ohlson2001,
Title title =
{Effects {{Effects of filtration rate on the glomerular barrier and clearance of four differently shaped
molecules},
Author molecules}},
author = {Ohlson, M. and S\"orensson, J. and Lindstr\"om, K. and Blom, A. M. and Fries, E. and Haraldsson,
B. },
Journal B.},
journal = {Am. J. Physiol. Renal Physiol.},
Year year = {2001},
Number number = {1},
Pages pages = {F103--113},
Volume volume =
{281} {281},
}
@Article{Ottewill1987,
Title = {Study of particle motion in concentrated dispersions by tracer diffusion},
Author = {Ottewill, R. H. and Williams, N. St. J.},
Journal = {Nature},
Year = {1987},
Pages = {232-234},
Volume = {325},
Publisher @Article{Ottewill1987,
title = {{Study of particle motion in concentrated dispersions by tracer diffusion}},
author = {Ottewill, R. H. and Williams, N. St. J.},
journal = {Nature},
year = {1987},
pages = {232-234},
volume = {325},
publisher = {Nature Publishing
Group} Group},
}
@Article{Paul2012,
Title title =
{Long-term {{Long-term stability of diluted solutions of the monoclonal antibody
rituximab},
Author rituximab}},
author = {Paul, M. and Vieillard, V. and Jaccoulet, E. and Astier,
A. },
Journal A.},
journal = {Int. J. Pharm.},
Year year = {2012},
Number number = {1-2},
Pages pages = {282--290},
Volume volume =
{436} {436},
}
@Article{Pitkanen2005,
Title title =
{Permeability {{Permeability of retinal pigment epithelium: effects of permeant molecular weight and
lipophilicity},
Author lipophilicity}},
author = {Pitk\"{a}nen, L. and Ranta, V. P. and Moilanen, H. and Urtti,
A. },
Journal A.},
journal = {Invest. Ophthalmol. Vis. Sci.},
Year year = {2005},
Number number = {2},
Pages pages = {641--646},
Volume volume =
{46} {46},
}
@Article{Pucadyil2006,
Title title =
{Confocal {{Confocal fluorescence recovery after photobleaching of green fluorescent protein in
solution},
Author solution}},
author = {Pucadyil, T. J. and Chattopadhyay,
A. },
Journal A.},
journal = {J. Fluoresc.},
Year year = {2006},
Number number = {1},
Pages pages = {87--94},
Volume volume =
{16} {16},
}
@Article{Sakurai2001,
Title title =
{Effect {{Effect of particle size of polymeric nanospheres on intravitreal
kinetics},
Author kinetics}},
author = {Sakurai, E. and Ozeki, H. and Kunou, N. and Ogura,
Y. },
Journal Y.},
journal = {Ophthalmic Res.},
Year year = {2001},
Number number = {1},
Pages pages = {31--36},
Volume volume =
{33} {33},
}
@Article{Srikantha2012,
Title title =
{Influence {{Influence of molecular shape, conformability, net surface charge, and tissue interaction on transscleral macromolecular
diffusion},
Author diffusion}},
author = {Srikantha, N. and Mourad, F. and Suhling, K. and Elsaid, N. and Levitt, J. and Chung, P. H. and Somavarapu, S. and Jackson, T.
L. },
Journal L.},
journal = {Exp. Eye Res.},
Year year = {2012},
Pages pages = {85--92},
Volume volume =
{102} {102},
}
@Article{Suhling2004,
Title title =
{Time-resolved {{Time-resolved fluorescence anisotropy imaging applied to live
cells},
Author cells}},
author = {Suhling, K. and Siegel, J. and Lanigan, P. M. and Leveque-Fort, S. and Webb, S. E. and Phillips, D. and Davis, D. M. and French, P.
M. },
Journal M.},
journal = {Opt. Lett.},
Year year = {2004},
Number number = {6},
Pages pages = {584--586},
Volume volume =
{29} {29},
}
@Article{Terpetschnig1995,
Title title =
{Metal-ligand {{Metal-ligand complexes as a new class of long-lived fluorophores for protein
hydrodynamics},
Author hydrodynamics}},
author = {Terpetschnig, E. and Szmacinski, H. and Malak, H. and Lakowicz, J.
R. },
Journal R.},
journal = {Biophys. J.},
Year year = {1995},
Number number = {1},
Pages pages = {342--350},
Volume volume =
{68} {68},
}
@Article{Urtti2006,
Title title =
{Challenges {{Challenges and obstacles of ocular pharmacokinetics and drug
delivery},
Author delivery}},
author = {Urtti,
A. },
Journal A.},
journal = {Adv. Drug Deliv. Rev.},
Year year = {2006},
Number number = {11},
Pages pages = {1131--1135},
Volume volume =
{58} {58},
}
@Book{VanHolde1998,
Title title =
{Principles {{Principles of Physical
Biochemistry},
Author Biochemistry}},
author = {Van Holde, K. E. and Johnson, W. C. and Ho, P. S.},
Publisher publisher = {Prentice Hall, New Jersey},
Year year =
{1998} {1998},
}
@Article{Venturoli2005,
Title title =
{Ficoll {{Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and
deformability},
Author deformability}},
author = {Venturoli, D. and Rippe,
B. },
Journal B.},
journal = {Am. J. Physiol. Renal Physiol.},
Year year = {2005},
Number number = {4},
Pages pages = {F605--613},
Volume volume =
{288} {288},
}
@Article{Weber1953,
Title title =
{Rotational {{Rotational {B}rownian motion and polarization of the fluorescence of
solutions},
Author solutions}},
author = {Weber,
G. },
Journal G.},
journal = {Adv. Protein Chem.},
Year year = {1953},
Pages pages = {415--459},
Volume volume =
{8} {8},
}
@Article{Weiss2004,
Title title =
{Challenges {{Challenges and artifacts in quantitative photobleaching
experiments},
Author experiments}},
author = {Weiss,
M. },
Journal M.},
journal = {Traffic},
Year year = {2004},
Number number = {9},
Pages pages = {662--671},
Volume volume =
{5} {5},
}
@Article{Wilkins1999,
Title title =
{Hydrodynamic {{Hydrodynamic radii of native and denatured proteins measured by pulse field gradient {N}{M}{R}
techniques},
Author techniques}},
author = {Wilkins, D. K. and Grimshaw, S. B. and Receveur, V. and Dobson, C. M. and Jones, J. A. and Smith, L.
J. },
Journal J.},
journal = {Biochemistry},
Year year = {1999},
Number number = {50},
Pages pages = {16424--16431},
Volume volume =
{38} {38},
}
@Article{Williams2005,
Title title =
{Topically {{Topically applied antibody fragments penetrate into the back of the rabbit
eye},
Author eye}},
author = {Williams, K. A. and Brereton, H. M. and Farrall, A. and Standfield, S. D. and Taylor, S. D. and Kirk, L. A. and Coster, D.
J. },
Journal J.},
journal = {Eye (Lond)},
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