Christopher Medway edited Introduction.tex  over 8 years ago

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\section{Introduction}  \textit{Yersinia} is a genus of gram-negative enterobacteriaceae. Of theeleven  characterised species of Yersinia, three have been particularly well studied due to their pathogenicity to humans; \textit{Y.pestis}, \textit{Y.pseudotuberculosis} and \textit{Y.enterocolitica}. \textit{Y.pestis} is highly pathogeneic, resulting in a systemic disease 'plague' the may affect the ('plague') which affects multiple organ systems;  lungs, lymph nodes and blood vessels. Conversly Conversly,  \textit{Y.pseudotuberculosis} and \textit{Y.enterocolitica} are entropathogens, enteropathogens,  primarily affecting the gastrointestinal system where they can cause local inflammation inflammation, diarrhea  and diarrhea. fever. Furthermore, while \textit{Y.pestis} is transmitted through flea bites, \textit{Y.enterocolitica} and \textit{Y.pseudotuberculosis} infections are primarily the result of consuming contaminated food/water. Other Yersinia species are not thought to be pathogenic to humans.  Given the range of Yersinia, and their variability in their pathogenicity, the ability to quickly pinpoint the Yersinia species from a sample is important for public health. This has been aided by the development of; i) high-throughput sequencing of whole bacterial genomes and, ii) databases of genomic features that confer pathogenicity to humans, such as YersinaBase (http://yersinia.um.edu.my/index.php/home/main).  \textit{Y.entrocolitica} strains are particularly diverse, containing a spectrum of non-pathogenic (1A), mildly-pathogenic (2-5) and pathogenic (1B) biovars.