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Christopher Medway edited Results and Discussion.tex
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The metabolic flexibility of \textit{Y.enterocolitica} biovars is known to the highly heterogeneous, with biovar 1A displaying the broadest metabolic potential \cite{Reuter}. Several metabolic pathways are known to be specific to certain Yersinia linieges; cobalamine biosynthesis (\textit{cob}), 1,2-propanediol utilisation(\textit{pdu}), tetrathionate respiration (\textit{ttr}) and [NiFe]-hydrogenase complexes (\textit{hyd2/4}).
Comparison of all functional catagories between our query \textit{Y.enterocolitica} biovar and a 'reference pathogenic' Y.enterocolitica strain 8081 (a 1B biovar) isolates a number of exclusive functional domains. Most strikingly, the pathogenic reference is enriched for; i) membrane transport protein, particularly of the type-III sectreation system, and ii) iron-aquasition and metabolism proteins.
Our query strain has a number of metabolic/functional catagories not found in the
pathogenic highly-pathogenic reference; i)
Coenzyme B12 biosynthesis ?? (\textit{pduO}), ii) RTX toxin cluster,
iii) ii) beta-Fimbriae
cluster (type VII secretion system),
iv) iii) Choloylglycine hydrolase and bile hydrolysis,
v) iv) Central meta-cleavage pathway of aromatic compound degradation,
vi) v) D-galactonate catabolism,
vii) vi) Aldehyde dehydrogenase B,
viii) vii) L-fucose
utilization**, ix) utilization, viii) N-Acetyl-Galactosamine and Galactosamine
Utilization**, x) Utilization, ix) Phage packaging machinery, Phage replication and Phage tail proteins and xi)Xanthosine utilization (xap region).
\cite{21798805} Interestingly it has been recently found that atypical, pathogenic 1A biovars contain the beta-Fimbriae cluster, Galactosmine utilisation pathways and RTX cluster, suggesting that may may confer some pathogenic potential \cite{21798805}.
Taken together, the phylogenetic analysis and genome annotation suggest that the query sequence is of a non-pathogenic strain (1A) of \textit{Y.enterocolitica}. Whilst not carrying any of the established markers of pathogenicity, the presence of several novel virulance features may confeer upon it a degree of pathogenic potential.