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Christopher Medway edited Block__332921452872802300.tex
over 8 years ago
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.. \subsection{Metabolism and Functional Pathways}
The metabolic flexibility of \textit{Y.enterocolitica} biovars is known to the highly heterogeneous, with biovar 1A displaying the broadest metabolic potential \cite{Reuter}. Several metabolic pathways are known to be specific to certain Yersinia linieges; cobalamine biosynthesis (\textit{cob}), 1,2-propanediol utilisation(\textit{pdu}), tetrathionate respiration (\textit{ttr}) and [NiFe]-hydrogenase complexes (\textit{hyd2/4}).
Comparison of all functional catagories between our query \textit{Y.enterocolitica} biovar and a 'reference pathogenic' Y.enterocolitica strain 8081 (a 1B biovar) isolates a number of exclusive functional domains. Most strikingly, the pathogenic reference is enriched for; i) membrane transport protein, particularly of the type-III sectreation system, and ii) iron-aquasition and metabolism proteins.
Our query strain has a number of metabolic/functional catagories not found in the highly-pathogenic reference; i) RTX toxin cluster, ii) beta-Fimbriae cluster (type VII secretion system), iii) Choloylglycine hydrolase and bile hydrolysis, iv) Central meta-cleavage pathway of aromatic compound degradation, v) D-galactonate catabolism, vi) Aldehyde dehydrogenase B, vii) L-fucose utilization, viii) N-Acetyl-Galactosamine and Galactosamine Utilization, ix) Phage packaging machinery, Phage replication and Phage tail proteins and xi)Xanthosine utilization (xap region). Interestingly it has been recently found that atypical, pathogenic 1A biovars contain the beta-Fimbriae cluster, Galactosmine utilisation pathways and RTX cluster, suggesting that may may confer some pathogenic potential \cite{21798805}.
Taken together, the phylogenetic analysis and genome annotation suggest that the query sequence is of a non-pathogenic strain (1A) of \textit{Y.enterocolitica}. Whilst not carrying any of the established markers of pathogenicity, the presence of several novel virulance features may confeer upon it a degree of pathogenic potential.
