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\textit{Introduction}  Alzheimer's disease (AD) is a incurable neurodegenerative disease, and the most common form of dementia. Clinically, AD typically manifests as cognitive decline with progressive episodic memory loss. Characteristic neuropathological hallmarks of AD include including  intracellular neurofibrillary.' neurofibrillary tangles of hyperphosphorylated tau protein and extracellular plaques