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\section{The era of the genome-wide association study}  The completion of the Human Geneome Project in 2003 ushered in a new era of genomics, and with it the expection that complex genetic diseases could now be tackled. Armed with a complete reference genome, understanding the variability between humans became a major focus of the International HapMap Project \href{http://hapmap.ncbi.nlm.nih.gov/} [http://hapmap.ncbi.nlm.nih.gov]  \cite{20811451}. 1184 1.6 million 11 different ethnic populations