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\textit{Introduction}  Alzheimer's disease (AD) is a incurable neurodegenerative disease, and the most common form of dementia.Clinically,  AD typically manifests clinically  as cognitive decline with progressive episodic memory loss. loss, although  Characteristic neuropathological hallmarks of AD including intracellular neurofibrillary tangles of hyperphosphorylated tau protein and extracellular plaques Whilst an early-onset, mendelian form of the disease exists (Early-onset Alzheimer's disease or EOAD), typically the results of highly penetrant autosomal dominant mutations in genes on the amyloid pathway (APP, PSEN1 and PSEN2), the late-onset form of the disease is more common accounting for ~95% of AD cases.