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\section*{How to use this template}  Please use this template for preparing your article for {\it F1000Research} in conjunction with our author guidelines (\url{http://f1000research.com/author-guidelines}). (\href{http://f1000research.com/author-guidelines}{author guidelines).  You may not need to complete all the sections below depending on the article type.   Please edit the sections below to add your article content and delete any sections that are not required for your article type.