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doi = {10.1007/7653_2015_46},  url = {http://dx.doi.org/10.1007/7653_2015_46},  year = {2015},  publisher = {Springer Science $\mathplus$ +  Business Media}, author = {David Ryan Koes},  title = {{Pharmacophore Modeling: Methods and Applications}},  booktitle = {Methods in Pharmacology and Toxicology},