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\subsection*{Estrogen Receptor $\beta$}  Virtual screening results for estrogen receptor $\beta$ are shown in Figure~\ref{erbeta}. The only method to None of the methods  outperform random selectionis RDKit with an AUC of 0.58  and all methods fail to exhibit early enrichment. Although shape constraints are capable of improving on the performance of both FOMS and VAMs, which both had an AUC of 0.43, the similarity methods,  they still lack significance and generally do not outperform RDKit. significance.