deletions | additions       diff --git a/subsection_Factor_XIa_Virtual_screening__.tex b/subsection_Factor_XIa_Virtual_screening__.tex  index 2631e39..66c2253 100644  --- a/subsection_Factor_XIa_Virtual_screening__.tex  +++ b/subsection_Factor_XIa_Virtual_screening__.tex 
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\subsection*{Factor XIa}  Virtual screening results for factor XIa (FXIA) are shown in Figure~\ref{fxia}. The optimizing All three  shape alignment of RDKit provides some enrichment with an AUC of 0.42. Although FOMS outperforms VAMS, both VAMS and FOMS similarity methods  perform worse than random with AUCs of ranging from  0.31 and (VAMS) to  0.42 for (RDKit and FOMS), with both  VAMS and FOMS respectively. failing to identify any actives early in the screen.  Shape constraints do not select enriched subsets and the pre-alignment methods exhibit no early enrichment behavior.These results suggest that although the shape of the query molecule provides some information, neither the placement of the fragment nor the whole molecule provides useful information for pre-alignment.