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\subsection*{Rho-Kinase2}  Virtual screening results Rho-Kinase2 are shown in Figure~\ref{rho} and are similar to those of PKA. FOMS achieves an AUC of 0.94, VAMS an AUC of 0.56, and RDKit and AUC of 0.34. The best shape constraints match or exceed the performance of FOMS. As with PKA, if a less selective fragment is used (a generic aromatic ring), virtual performance is substantially reduced (data not shown), although, as with PKA, FOMS still outperforms RDKit and VAMS in this case.