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Pybel \cite{pybel} provides the full functionality of Open Babel, but common routines are provided in a simplified, more `pythonic' interface.  rcdk \cite{guha2007chemical} provides an R interface to the CDK and working with fingerprints.  RDKit is a substantial cheminformatics toolkit written in C++ with Python, Java and C\# bindings. Its capabilities include file handling, manipulation of molecular data, chemical reactions, substantial support for fingerprinting, substructure and similarity search, 3D conformer generation, property determination, force field support, shape-based alignment and screening, and integration with PyMOL, KNIME, and PostgreSQL.  rubabel \cite{Smith_2013} is similar to Pybel in that it provides a native Ruby interface to Open Babel.