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Chem$^f$ \cite{H_ck_2012} is a minimal cheminformatics toolkit written in the functional language Scala.  Galaxy \cite{Goecks_2010} is a web platform for exploring biomedical data and includes as a component a Chemical Toolbox that integrates a number of other cheminformatics tools to offer an array of molecular search, property calculation, clustering, and manipulations capabilities.  \paragraph{Graphical Development Environments}  Ambit \cite{Jeliazkova_2011} integrates with CDK to provide web-based applications for chemical search and analysis.