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Chem$^f$ \cite{H_ck_2012} is a minimal cheminformatics toolkit written in the functional language Scala.  chemfp \cite{dalke2011chemfp} is a high-performance library with a Python interface for generating and searching for molecular fingerprints.  chemkit is a C++ cheminformatics toolkit that includes support for visualization with the Qt framework and molecular modeling.  ChemmineR \cite{Cao_2008} is a cheminformatics package for the R statistical programming languages language  that is built using Open Babel. Its capabilities include property calculations, similarity search, and classification and clustering of compounds. Cinfony \cite{cinfony} provides a single, simple standardized interface to other cheminformatics toolkits, including Open Babel, RDKit, the CDK, Indigo, JChem, OPSIN, and several web services.