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Scott Fay,
Kyle Taylor
Molecular manipulation of the genetic pathways of living organisms Synthetic biology has
the potential to change lives in many ways, such as had profound effects on human life, for example, providing more effective anti-malarial medicine,
cheaper insulin, or useful
bio-materials like spider silk grown from bacteria. [Insulin, previously extracted from animals, was expensive and scarce until the gene was inserted into bacteria and breakthrough human insulin became widely available.] The field of synthetic biology is still in its infancy and bio-materials. However, much remains to be learned
about how to most efficiently stitch [these] genetic parts together. Generally, researchers combine promoters and genes in order to
produce a desired protein. However, the amount of protein present in the cell is synthesize more
than just proteins efficiently. We developed a
function bioinformatics workshop to study possible determinants of
its promoter. Protein protein levels
are typically measured by RNA levels, as RNA polymerase recognizes and binds promoters, but in
fact RNA levels are often poor predictors of protein levels. Factors such as protein degradation rate or translation initiation (the topic under consideration here) are important to consider as well. plants. We
present extracted possible ribosome binding and translation initiation
candidate DNA parts derived from publicly available data sequences and
look looked for correlations
to with experimentally determined protein levels,
using publicly available data sets focusing on the widely studied plants Oryza sativa and Arabidopsis thaliana. The working group
is was open to the public and
we have had over 50 individuals participate to date. The group meets met every other week for 3
hours hours, typically starting with a short presentation related to the session’s agenda followed by hands-on data work. We
hope our experience will serve as a model for future community projects that serve the dual purpose of educating curious members of the public while also generating useful scientific results. We aim to develop and experimentally validate our consensus sequences for publication with hopes that our work will be useful for researchers in plant synthetic biology, such as the Glowing Plant Project initiated at the BioCurious community laboratory in Sunnyvale,
California. California.We hope our experience will serve as a model for future community projects that serve the dual purpose of educating curious members of the public while also generating useful scientific results.