Several biomarkers for AD are currently being studied across the world. These biomarkers have different relevance at different stages of AD progression. Jack et al \cite{Jack2010,Jack_2013} describe the temporal evolution of AD biomarkers and their interrelationships amongst themselves, and with the onset and progression of clinical symptoms. Currently there are five established biomarkers of AD. One of these is the progressive loss of cognitive functions. However, this external symptom appears years after the changes in the other biomarkers. In the following sections we consider state of the remaining four biomarkers individually.