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Alois Alzheimer in 1907 reported \cite{Alzheimer1907,stelzmann1995} a study of one of his patients with "an unusual illness of the cerebral cortex".  Alzheimer details the symptoms of his patient suggesting that they were so unusual that the patient could not be classified as having one of the recognized illnesses.  "The "\textit{The  first symptom the 51-year-old woman showed was the idea that she was jealous of her husband. Soon she developed a rapid loss of memory.  She was disoriented in her home, carried things from one place to another and hid them, sometimes she thought somebody was trying to kill her and started to cry loudly. ... As the illness progressed, these phenomena which are to be interpreted as complex symptoms appear sometimes stronger, sometimes weaker.  But they are never severe. 
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the nucleus and the cell itself disintegrate and only a tangle of fibrils indicates the place where a neuron was previously located. ...  Many neurons, especially the ones in the upper layer, have completely disappeared. ...  Distributed all over the cortex, but especially numerous in the upper layers, there are minute miliary foci which are caused by the deposition of a special substance in the cortex. ...  Considering everything, it seems we are dealing here with a special illness." illness.}"  More than a century now, indeed Alzheimer was right that he was dealing with a special illness which is now named after himself, as Alzheimer's Disease (AD).  Ever since this first reporting, several studies have been performed in the past century and in particular the last couple of decades.