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\section{Biomarkers of for  AD } The entities whose presence, concentration or activity are associated with a disease are known as the biomarkers for that disease.  Several biomarkers for AD are currently being studied across the world.  These biomarkers have different relevance at different stages of AD progression.  Jack et al \cite{Jack2010,Jack_2013} describe the temporal evolution of AD biomarkers and their interrelationships amongst themselves, and with the onset and progression of clinical symptoms.