deletions | additions       diff --git a/Structural_changes_seen_in_MRI__.tex b/Structural_changes_seen_in_MRI__.tex  index 6f89ec4..fed9acc 100644  --- a/Structural_changes_seen_in_MRI__.tex  +++ b/Structural_changes_seen_in_MRI__.tex 
...
Longitudinal structural MRIs have been widely used as an imaging biomarker for AD.  At present, brain atrophy is measured from the high-resolution acquisitions with MRI scanners of 1.5T or 3T magnets.  The best established and validated atrophy assessment are based on T1-weighted MRIs \cite{Frisoni2010}.  Structural changes seen in MRI correlates well with the cognitive impairment \cite{Jack_2013}.  By this time, A$\beta$ abnormality is already saturated.  Thus for monitoring the impact of disease modifying drugs, the ability to track and predict structural changes in MRI can play an important role.