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Explanation of different biomarkers used in studying the evolution of AD. And explanation of why structural imaging (MR) is important.  \\  The loss of brain volume observed in 3D brain structural Magnetic Resonance Image (MRI) is one of the indicators characterizing AD \cite{Mueller2005}.  There has been growing interest in a longitudinal and cross-sectional analysis of MRI brain images to better understand how atrophy occurs in AD \cite{Sabuncu2011}\cite{Jack2009}\cite{Frisoni2010}. \cite{Sabuncu2011,Jack2009,Frisoni2010}.  In longitudinal studies different brain scans of an individual taken at different times are considered. In cross-sectional studies, analysis is done from different brain scans of different individuals.  With growing number of analysis and quantifying techniques for the brain atrophy it becomes imperative to have a methodical approach to compare and validate these techniques by creating a gold standard data.