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\label{fig:ADDeficiencies_Herrup2015} Figure reproduced from \cite{Herrup_2015}: Figure shows the possible causes of AD grouped into three main categories grouped into ovals above: (top oval) cellular events, \textbf{cellular events},  (bottom left oval) molecular events \textbf{molecular events}  showing the sequences that result in two hallmarks of AD: NFTs and senile plaques, (bottom right oval) genetic events \textbf{genetic events}  showing the risk factor genes where PSEN2, PSEN1 and APP are emphasized to indicate their involvement in fAD. genes. See \cite{Herrup_2015} for detailed description.