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Bishesh Khanal edited Both_CSF_and_imaging_biomarkers__.tex
about 8 years ago
Commit id: 5341c024594fa6e8ee92faf6dfca053ac25c0caa
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Both CSF and imaging biomarkers targeting A$\beta$
plaques pathophysiology are available and have been widely used in AD research.
Widely used CSF biomarker is the decreased level of amyloid-$\beta_{1-42}$ (A$\beta42$) in AD while the imaging biomarker is the increased level of Pittsburgh compound in AD patients.
A$\beta_{42}$ is 42-amino-acid form of A$\beta$ and is believed to be lowered when it gets converted to A$\beta$ plaques.
This view is consistent to the findings of inverse relationship between CSF A$\beta42$ levels and Pittsburgh compound that binds with A$\beta$ plaques level \cite{Fagan_2006}.