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\section{Potential Biomarkers of AD }  Several biomarkers for AD are currently being studied across the world.  These biomarkers have different relevance at different stages of AD progression.  Jack et al \cite{20083042} \cite{Jack} \cite{Jack2010,Jack2013}  \fixme{Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers} describe the temporal evolution of AD biomarkers and their interrelationships amongst themselves, and with the onset and progression of clinical symptoms. Explanation of neurofibrilary tangles, amyloid plaques and different hypotheses.  \subsection{Metrics Derived from Imaging}