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David Andrew Eccles edited Bootstrap Sub-sampling.tex
almost 9 years ago
Commit id: b283191ec5e518c0d7e8fb3078394887705ce8e9
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SNPs had a maximum rank below 5000, whereas most of the remaining
489574 SNPs had a maximum rank above 350000 (see
Figure~\ref{fig:sig-thy-bootstrap-consistency}-B).
The bootstrap sub-sampling method was used to eliminate those markers
from the initial X chromosome filtered set of 490032 SNPs that were
not effective for genetically distinguishing case and control groups.
In each iteration of the bootstrap process, a sub-sample of
individuals from each group was carried out, then markers were ranked
based on a statistic that evaluates the effectiveness of each marker
(see Figure~\ref{fig:bootstrap-procedure}). Markers that consistently
had a high association statistic in each bootstrap sub-sample were
selected for the next stage in the process.