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David Andrew Eccles edited Background.tex
almost 9 years ago
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%% New/Improved bioinformatics algorithm/method for identification of
%% genomic signatures for predicting disease/trait
% Multi-region Ethics Committee (National)
% MEC/05/12/174
% My process [from 490032 SNPs]
% * bootstrap by chi^2 (50% pseudo-samples, with replacement)
% * sort by bootstrap
...
to construct such profiles. Hence the prediction of genetic risk is a
major challenge of the $21^{st}$ century.
The introduction of large-scale Single Nucleotide Polymorphism (SNP) genotyping systems has enabled genetic variants to be typed \textit{en-masse}, shifting the main effort required in a genetic risk study from genotyping to data analysis (or bioinformatics).
The
investigation of Here we investigate genetic markers for Type 1 Diabetes
(T1D) in this
chapter is a demonstration of (T1D), demonstrating how a population sub-sampling method
developed in the previous chapter may assist in the identification of risk markers for a complex disease.
\subsection{Type 1 Diabetes}
\label{sec:sig-thy-t1dintro}
...