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It is essential that this set be externally validated in  other populations, but given reasonable validation the set may also be  used for a global indicator of T1D risk. In any case, Even without such validation,  the Wellcome Trust study was a fairly large study that recruited a substantial proportion of UK individuals. Given this,  the signature set of 5 GSMs identified here should be suitable for estimating T1D risk for screening purposes in at least the UK population.