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Shan H. Siddiqi edited section_Methods_subsection_Subjects_We__.tex
almost 9 years ago
Commit id: 4cec4ca39487466f3a70ecbf4ce8229aa50754a0
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All subjects received a standard clinical protocol with high frequency (10Hz) rTMS over the left dorsolateral prefrontal cortex (DLPFC) at 4000 pulses for up to 20 treatments with a Magpro R30 device (MagVenture, Tonica Elektronik – Denmark). Additional slow (1Hz) rTMS at 600 – 1200 pulses over the right DLPFC was used for augmentation as needed. Investigators providing rTMS treatments were not aware of patients' TCI profiles until the treatment course was completed.
\subsection{Statistical analyses}
Treatment response was defined as ≥50\% decrease in Hamilton Depression Rating Scale
(HRDS) (HDRS) scores. Baseline scores on each TCI dimension were compared between responders and nonresponders via unpaired t-test calculated with Microsoft Excel 2010. The threshold for significant p-value was set at 0.007 based on Bonferroni correction due to presence of seven simultaneous comparisons. Temperament/character scores were also subjected to linear regression analysis against percentage improvement in HDRS.
Pearson correlation coefficients were compared for each temperament/character score against baseline HDRS score and percentage improvement in HDRS.