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<p><br></p><div><u>The forces of attraction cause two cell join</u> <br></div><p> The human organ system is complexity but
understands the micro structure of each organ how it grow in the organ we must
to know how is the cell grow one to other. As well as analysis diseases are
really difficult. Even so cantilever mechanical and system can help us achieve
this solve of degree of freedom in differentials equation govern by mechanism. The Cell adhesion to the binding of the cell on
the surface with other cell , Usually, this analysis based on label –free which
the cell sensing signal to the centered cell the cell attract force to other cell join ( Figure.9.).
The research from Giaver and Keese
investigated the behavior of two fibroblast cell lines on the gold electrodes
under electric field with high frequency 4000Hz. The conclusion show that the
force join and spreading of these cells depend on the impedance of the
biosensor syste. The impedance of force [<cite class="squire-citation ltx_cite" data-bib-text="@article{Fang_2011,
doi = {10.4061/2011/460850},
url = {http://dx.doi.org/10.4061/2011/460850},
year = 2011,
publisher = {Hindawi Publishing Corporation},
volume = {2011},
pages = {1--16},
author = {Ye Fang},
title = {Label-Free Biosensors for Cell Biology},
journal = {International Journal of Electrochemistry}
}" data-bib-key="Fang_2011" contenteditable="false" style="cursor: pointer"><a class="au-cite-link" href="#Fang_2011">Fang 2011</a></cite>] cell fluctuated with time and so
sensitive into actininhibitor and cytochalasin B, and research found that
electric biosensor can used to detect the micro motions of cantilever move as Nano lever [<cite class="squire-citation ltx_cite" data-bib-text="@article{Giaever_1991,
doi = {10.1073/pnas.88.17.7896},
url = {http://dx.doi.org/10.1073/pnas.88.17.7896},
year = 1991,
month = {sep},
publisher = {Proceedings of the National Academy of Sciences},
volume = {88},
number = {17},
pages = {7896--7900},
author = {I. Giaever and C. R. Keese},
title = {Micromotion of mammalian cells measured electrically.},
journal = {Proceedings of the National Academy of Sciences}
}" data-bib-key="Giaever_1991" contenteditable="false" style="cursor: pointer"><a class="au-cite-link" href="#Giaever_1991">Giaever 1991</a></cite>] . The research concluded that
electronic sensor can detect the living cells [<cite class="squire-citation ltx_cite" data-bib-text="@article{Fang_2011,
doi = {10.4061/2011/460850},
url = {http://dx.doi.org/10.4061/2011/460850},
year = 2011,
publisher = {Hindawi Publishing Corporation},
volume = {2011},
pages = {1--16},
author = {Ye Fang},
title = {Label-Free Biosensors for Cell Biology},
journal = {International Journal of Electrochemistry}
}" data-bib-key="Fang_2011" contenteditable="false" style="cursor: pointer"><a class="au-cite-link" href="#Fang_2011">Fang 2011</a></cite>]. Understand of how the cell
behavior electronic sensor with and signaling are the device .Along with attract
force, the boundary condition cell growth will affect the movement cantilever <br></p><p><u>Cell
Boundary condition Functions:</u><br></p><p>For
investigating cell barrier functions, the biosensor can offer insights how the
cell barrier function of each cell are regulated using the technique
penetration depth or sensing volume with optical biosensor which can understand and resolve how the cell
matrix interactions using the mathematical modeling (12,13).The example
technique to measure of the functions with Electric Cell Substrate impedance
Sensing (ECIS) (14)is the complicated by multiple types of resistance in the
cell to cell ,in the cell to matrix and transcellular resistance (15) The electrical biosensors provide an
aggregated measurement and integrates better understand cell to cell and cell
to matrix interactions. As well the cell
communication one to other<br></p><div>��1A})�<br></div>
