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Veronica edited M&M - radial dose - real spectra and ionization rates.tex
almost 9 years ago
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The actual shape of the radial dose profile to be found in a realistic treatment
irradiation was obtained through a weighted superposition of
the monoenergetic profiles, using specific photon spectra. For this work, spectra resulting from 160 kVp, 6 and 15 MV irradiation in water were analysed to evaluate the GNP ionization rate.
It was observed that the different energy spectra shapes were not fundamental to the investigation, as the only relevant parameter resulted to be the probability of ionization per nanoparticle per Gy. An example of the radial energy deposition profile evaluated for the simulated photon and secondary electron
spectrum spectra of a 6 MV Linac, sampled at a depth of 5 cm in a water phantom, is reported in Figure \ref{radial_dose}, panel B and C. The obtained dose distribution profiles were used as input to a radial function which was exploited to calculate the number of lethal events upon a determinate distance from the nanoparticles center.