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Andrea Attili edited M&M - radial dose - real spectra and ionization rates.tex
over 9 years ago
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For this work, spectra resulting from 160 kVp, 6 and 15 MV irradiation in water were analysed to evaluate the GNP ionization rate. It was observed that the different energy spectra shapes were not fundamental to the investigation, as the only relevant parameter resulted to be the probability of ionization per nanoparticle per Gy. An example of the radial energy deposition profile evaluated for the simulated photon and secondary electron spectrum of a 6 MV Linac, sampled at a depth of 5 cm in a water phantom, is reported in figure [radial dose, panel B and C]. The obtained dose distribution profiles were used as input to a radial function which was exploited to calculate the number of lethal events upon a determinate distance from the nanoparticles center. GNPs ionization rates were extrapolated from the simulations and found to be $4 \times 10^{−7}$, $2.35 \times 10^{−7}$ and $2.25 \times 10^{−7}$ per GNP per Gy for 160 kVp, 6 and 15 MV respectively. The latter values are in line with what would be expected at megavoltage energies by the gold mass attenuation coefficient and are consistent with those
calculated reported in \cite{McMahon_2011}.