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The actual shape of radial dose profiles to be found in a realistic treatment was obtained through a weighted superposition of monoenergetic profiles, using specific photon spectra. For this work, spectra resulting from 160 kVp, 6 and 15 MV irradiation in water were analyzed to evaluate GNPs ionization rate (figure \ref{radial_dose}, panel B). The obtained dose distribution profiles were used as input to a radial function which was exploited to calculate the number of lethal events upon a determinate distance from the nanoparticles center.         

Introduzione.tex  Mat&Met - dose radial profile.tex  figures/radial-dose-article1/radial-dose-article1.png  M&M - radial dose - real spectra and ionization rates.tex  M&M - LEM.tex  M&M - LEM-AM.tex  M&M - stochastic.tex