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The high radiosensitization induced at kilovoltage energies by gold nanoparticles is well documented by both _in vitro_ and _in vivo_ studies (mice with implanted tumors) \cite{Hainfeld_2004,Hainfeld_2004,Kong_2008,Rahman_2009,Jain_2012}. As an example, irradiation of cells loaded with gold foils reported dose enhancement factors higher than 100 \cite{Regulla_1998,Regulla_2002}. As the concentration of nanoparticles increases the radiosensitization increases \cite{Rahman_2009,Lechtman_2013,Ranjbar_2010}, due to the higher number of photoelectric interactions and consequently higher dose deposition as well as an additional oxidative stress induced by the presence of nanoparticles [Pan09, Kan10]. Experimental studies have revealed that gold nanoparticles radiosensitization are also highly sensitive to photon source energy [Chi10, Asg10], cancer cell type [Pat07, Jai11], nanoparticle size [But12] and their localization relative to cellular DNA [Bru09].  diff --git a/layout.md b/layout.md  index d5c12a9..e0b213b 100644  --- a/layout.md  +++ b/layout.md 
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Abstract.tex  Introduzione.tex  Intro - keV.md