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}  @article{22355537,  title @article{McMahon_2011a,  abstract  = {{Biological consequences {Gold nanoparticles (GNPs) are being proposed as contrast agents to enhance X-ray imaging and radiotherapy, seeking to take advantage  of nanoscale the increased X-ray absorption of gold compared to soft tissue. However, there is a great discrepancy between physically predicted increases in X-ray  energy depositionnear irradiated heavy atom nanoparticles.}},  date = {2011},  source = {Sci Rep},  authors = {McMahon, SJ and Hyland, WB and Muir, MF and Coulter, JA  and Jain, S and Butterworth, KT and Schettino, G and Dickson, GR and Hounsell, AR experimentally observed increases in cell killing. In this work, we present the first calculations which take into account the structure of energy deposition in the nanoscale vicinity of GNPs  and O'Sullivan, JM relate this to biological outcomes,  and Prise, KM show for the first time good agreement with experimentally observed cell killing by the combination of X-rays  and Hirst, DG GNPs. These results are not only relevant to radiotherapy, but also have implications for applications of heavy atom nanoparticles in biological settings or where human exposure is possible because the localised energy deposition high-lighted by these results may cause complex DNA damage, leading to mutation  and Currell, FJ}, carcinogenesis.},  author = {McMahon, SJ Stephen J  and Hyland, WB Wendy B  and Muir, MF Mark F  and Coulter, JA Jonathan a  and Jain, S Suneil  and Butterworth, KT Karl T  and Schettino, G Giuseppe  and Dickson, GR Glenn R  and Hounsell, AR Alan R  and O'Sullivan, JM Joe M  and Prise, KM Kevin M  and Hirst, DG David G  and Currell, FJ},  year Fred J},  doi  = {2011},  month {10.1038/srep00018},  file  = {}, {:home/andrea/Documents/Mendeley Desktop/McMahon et al. - 2011 - Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles(2).pdf:pdf},  issn = {2045-2322},  journal = {Sci Rep},  volume {Scientific reports},  keywords  = {1},  number {Animals,Apoptosis,Apoptosis: radiation effects,Biological,Computer Simulation,Dose-Response Relationship,Energy Transfer,Energy Transfer: physiology,Energy Transfer: radiation effects,Gold,Gold: radiation effects,Heavy Ions,Humans,Metal Nanoparticles,Metal Nanoparticles: radiation effects,Models,Radiation,Radiation Dosage},  mendeley-groups  = {}, {nATT/Radiobiologia,Bibliografia articoli/nATT},  month = jan,  pages = {18}, pubmed_id pmid  = {22355537}, title = {{Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles.}},  url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3216506\&tool=pmcentrez\&rendertype=abstract},  volume = {1},  year = {2011}  }