Andrea Attili edited M&M - radial dose - real spectra and ionization rates.tex  over 9 years ago

Commit id: 06a0f3f84d5da11d313a47226aa023ced9fa464f

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The actual shape of the radial dose profile to be found in a realistic treatment irradiation was obtained through a weighted superposition of the monoenergetic profiles, using specific photon spectra.  For this work, spectra resulting from 160 kVp, 6 and 15 MV irradiation in water were analysed to evaluate the GNP ionization rate. It was observed that the different energy spectra shapes were not fundamental to the investigation, as the only relevant parameter resulted to be the probability of ionization per nanoparticle per Gy. An example of the radial energy deposition profile evaluated for the simulated photon and secondary electron spectrum of a 6 MV Linac, sampled at a depth of 5 cm in a water phantom, is reported in Figure \ref{radial_dose}, panel B and C. The obtained dose distribution profiles were used as input to a radial function which was exploited to calculate the number of lethal events upon a determinate distance from the nanoparticles center.