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\end{itemize}  Solving the problem  \begin{itemize}  \item Treat as absorbing boundary with drift, and solve the diffusion equation (see page 3 of Payam's paper. \cite{http://pre.aps.org/abstract/PRE/v87/i4/e042723}). \citet{10.1103/PhysRevE.87.042723}).  %  \item If we can make free energy change zero, then $\langle e^{-\beta W}\rangle = 1$. With dissipative process.  \end{itemize}